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An Amazon cargo Boeing 767-300 overran the runway at Miami International Airport.
The plane struck several vehicles and caught fire after the crash.
Officials said at least five people were killed and multiple others were injured.
The flight had arrived from San Juan, Puerto Rico.
Why it mattersA cargo jet crash at Miami could disrupt deliveries and raise safety scrutiny.
More context
Airport operations were affected, with flights temporarily halted.
The Federal Aviation Administration and the National Transportation Safety Board are investigating.
Amazon expressed condolences and said it is cooperating with local authorities.