Russian drone strikes hit a shopping center in Kryvyi Rih, the hometown of President Zelenskyy.
At least 14 people were killed and between 121 and 130 others were reported injured.
President Zelenskyy described the incident as a 'double-tap' attack targeting first responders.
Local authorities reported that multiple attacks across Ukraine on Friday caused 21 total deaths.
More context
Zelenskyy characterized the strikes as terrorist acts and vowed a military response.
The incident occurred amid an intensifying Russian missile campaign against major Ukrainian cities.
In retaliation, Ukraine has been using domestic drones to hit industrial and military targets in Russia.
Ukraine launched strikes against a Russian oil refinery and a military airfield recently.
Aerial activity has increasingly affected the airspace of neighboring Poland, Romania, and Moldova.
The shopping mall strike is one of several recent high-casualty incidents in civilian areas.
Rescue operations continued as officials assessed the full extent of the damage.
Russia has not yet issued a specific formal statement regarding the shopping center strike.